Microbiome Dysbiosis (3) Prototypes of Dysbiosis-Induced Disease (VIDEO:1hour,42minutes=102minutes)

UPDATE Feb-Mar 2025: I’ve noticed that some of the videos previously posted/streaming from the Vimeo platform are no longer reliably visible, while at the same time, this Substack platform has progressively allowed for direct uploading/embedding of videos; as such, many of the previously-posted videos are being reloaded directly into the Substack platform for more reliable access and archiving.

Video #3: Prototypic Clinical Patterns of Dysbiosis-Induced Disease

Objectives and Clinical Importance:

• Explain and demonstrate appropriate clinical management of the dysbiotic component of the listed prototypic conditions:

  • Dysbiotic encephalopathies:

    • Hepatic encephalopathy

    • D-lactic acidosis

    • Autobrewery syndrome—one of the irrefutable prototypes of dysbiosis wherein an intestinal overgrowth of yeast ferments dietary carbohydrate into ethanol, allowing persons to become inebriated “drunk” with alcohol despite no intentional/direct/oral intake of alcoholic beverages.

  • Fibromyalgia—this pain syndrome is well-known to be caused by SIBO, which results in mitochondrial dysfunction and activation of the NLRP3 inflammasome, resulting in neuroinflammation and central sensitization to pain

  • Atopic dermatitis / eczema—well-known to be proximally triggered by bacterial inflammogens and an IgE-mediated response to skin bacteria, especially Staphylococcus aureus

  • Insulin resistance and type-2 diabetes—causatively linked with an inflammatory dysbiosis as well as possible dermal overgrowth of Staphylococcus aureus

  • Psoriasis—well-known, thanks largely to the work of Dr Patricia Noah and colleagues, to be triggered by multifocal polydysbiosis

  • Bowel-associated dermatitis arthritis syndrome, short-bowel syndrome—a very elegant model of the effects of SIBO, resulting in multicomponent pathophysiology including generalized inflammation, immune-complex pathophysiology resulting in arthritis/dermatitis/vasculitis, and also cell-mediated bacterial allergy

• Analyze/Interpret: Laboratory results for significance and/or lack thereof; judicious analysis

• Identify: Actionable alterations in microbial patterns, phenotypes of dysbiosis-induced disease

• Implement: Treatment plans consistent with the 4 main components of evidence-based medicine

• Must be able to name and clinically apply a 3-pronged treatment plan addressing each of the 3 main components of dysbiosis

Clinical narrative: The information in this presentation completes the next step in our translation of molecules via pathophysiologic responses to various “patterns of inflammation” that distill into various clinical prototypes; by appreciating these prototypes, clinicians can see the clinical presentation of various patterns of dysbiosis-induced disease

All videos from the course HUMAN MICROBIOME AND DYSBIOSIS IN CLINICAL DISEASE are being re-uploaded in Feb-Mar 2025 to provide direct and reliable access through the substack platform:

1. Can you answer these 10 questions on dysbiosis and microbiome?

2. VIDEO with discussion of QUESTIONS and ANSWERS 1-5 with Test-Taking Strategies

3. QUESTIONS and ANSWERS for Dysbiosis & Microbiome (6-10) with Test-Taking Strategies

4. Microbiome Dysbiosis (1) Course Overview and Introduction to Major Concepts and Mechanisms

5. Microbiome Dysbiosis (2) Physiologic and Pathologic Mechanisms of Dysbiosis and Subclinical Microbial Colonizations (VIDEO:1hour,15minutes)

6. Microbiome Dysbiosis (3) Prototypes of Dysbiosis-Induced Disease (VIDEO:1hour,42minutes=102minutes)

7. Microbiome Dysbiosis (4) Conceptual Expansion Exploring Clinical Testing, Microbial Relevance and Irrelevance [VIDEO:1hour,18minutes=78minutes]

8. Microbiome Dysbiosis (5) Microbial Consequences in the Mouth, Oral Cavity [VIDEO:1hour,44minutes=104minutes]

9. Microbiome Dysbiosis (6) Microbial Imbalances in the Respiratory Tract and Sinuses [VIDEO:1hour,35minutes=95minutes]

10. Microbiome Dysbiosis (7) Dysbiosis by Location—Genitourinary Tract

11. Microbiome Dysbiosis (8) Dysbiosis by Location—Blood, Tissue, Parenchymal Dysbioses

12. Microbiome Dysbiosis (9) Dysbiosis by Location—Skin and Environmental Dysbiosis

13. and several other videos for many hours more—these will be posted progressively over the next few days into March2025

My course on “Human Microbiome and Dysbiosis in Clinical Disease” was developed over several years starting formally in 2015-2017 as a continuing medical education (CME) postgraduate online conference joint-accredited for doctors, nurses, and pharmacists:

• “American Medical Association Physician's Recognition Award (AMA PRA) Category 1 Statement: This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership … accredited by the ACCME to provide continuing medical education for physicians. …designates this educational activity for a maximum of 30 AMA PRA Category 1 credits.

• Nursing Statement: …approved provider of continuing nursing education by the Washington State Nurses Association WSNA A-CNE, an accredited Approver of Continuing Nursing Education.

• Pharmacy Statement: …accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Objectives appropriate for pharmacists.”

I’ve established legitimate expertise on this topic for more than 20 years via clinical experience, post-graduate conference presentations, book publications, and numerous peer-reviewed professional publications.

1. Dr Alex Vasquez. Reducing pain and inflammation naturally - Part 6: Nutritional and Botanical Treatments Against “Silent Infections” and Gastrointestinal Dysbiosis, Commonly Overlooked Causes of Neuromusculoskeletal Inflammation and Chronic Health Problems. Nutritional Perspectives 2006 Jan

2. Dr Alex Vasquez. Neuroinflammation in fibromyalgia and CRPS is multifactorial. Nat Rev Rheumatol 2016 Apr;12(4):242. doi: 10.1038/nrrheum.2016.25 pubmed.ncbi.nlm.nih.gov/26935282

3. Dr Alex Vasquez. Biological plausibility of the gut-brain axis in autism. Ann N Y Acad Sci 2017 Nov;1408(1):5-6. doi: 10.1111/nyas.13516 pubmed.ncbi.nlm.nih.gov/29090837

4. Dr Alex Vasquez. Musculoskeletal Pain: Expanded Clinical Strategies: Printed monograph approved for ACCME PRA-1 Continuing Medical Education ncbi.nlm.nih.gov/nlmcatalog/101633549 Published by: Institute for Functional Medicine. 2008 May

5. Dr Alex Vasquez. Mitochondrial Medicine Arrives to Prime Time in Clinical Care: Nutritional Biochemistry and Mitochondrial Hyperpermeability ("Leaky Mitochondria") Meet Disease Pathogenesis and Clinical Interventions. Integr Med (Encinitas) 2014 Aug;13(4):44-9 pubmed.ncbi.nlm.nih.gov/26770108

6. Dr Alex Vasquez. Reply to "role of Western diet in inflammatory autoimmune diseases" by Manzel et al. In current allergy and asthma reports (volume 14, issue 1, January 2014). Curr Allergy Asthma Rep 2014 Aug;14(8):454. doi: 10.1007/s11882-014-0454-4 pubmed.ncbi.nlm.nih.gov/24947682

7. Dr Alex Vasquez. Correspondence regarding Cutshall, Bergstrom, Kalish's "Evaluation of a functional medicine approach to treating fatigue, stress, and digestive issues in women" in Complement Ther Clin Pract 2016 May. Complement Ther Clin Pract 2018 May;31:332-333. doi: 10.1016/j.ctcp.2016.10.001 pubmed.ncbi.nlm.nih.gov/27814977

8. Dr Alex Vasquez. The Microbiome Arrives to Prime Time in Primary Care, Implications for the Anti-Dysbiotic Treatment of Fibromyalgia. Nutritional Perspectives 2015 Oct

9. Dr Alex Vasquez. Translating Microbiome (Microbiota) and Dysbiosis Research into Clinical Practice: The 20-Year Development of a Structured Approach that Gives Actionable Form to Intellectual Concepts. International Journal of Human Nutrition and Functional Medicine 2015 Jun

   

   

   

Currently, my largest and most detailed explanation of dysbiosis-microbiome is in Inflammation Mastery 4th Edition currently available at discounted price directly from the publisher:

Sample PDF downloads: ​

• Click here to see the cover

• Click here to see the first few pages, including the table of contents and index (size: 6 MB)

• Click here for a larger sample with photos (size: 43 MB)

[Adding a paywall line is necessary due to changes in Substack formatting requirements but nothing is added below this line]